How to cite item

Markers of resistance to anti-EGFR therapy in colorectal cancer

   
@article{JGO1154,
	author = {Walid Shaib and Reena Mahajan and Bassel El-Rayes},
	title = {Markers of resistance to anti-EGFR therapy in colorectal cancer},
	journal = {Journal of Gastrointestinal Oncology},
	volume = {4},
	number = {3},
	year = {2013},
	keywords = {},
	abstract = {Epidermal growth factor receptor (EGFR) is a therapeutic target in colorectal cancer (CRC). The benefit from EGFR inhibitors appears to be limited to a subset of patients with CRC. Mechanisms of resistance to EGFR inhibitors are being identified. KRAS codon 12 activating mutation is a predominate mechanism of resistance to EGFR inhibitors in around 40% of patients with advanced CRC. Other potential mechanisms of resistance include ligand expression, increased EGFR number, mutations of BRAF and activation of alternate signaling pathways.},
	issn = {2219-679X},	url = {https://jgo.amegroups.org/article/view/1154}
}