Colorectal carcinoma: Pathologic aspects
Abstract
Colorectal carcinoma is one of the most common cancers and one of the leading causes of cancerrelated
death in the United States. Pathologic examination of biopsy, polypectomy and resection specimens
is crucial to appropriate patient managemnt, prognosis assessment and family counseling. Molecular testing
plays an increasingly important role in the era of personalized medicine. This review article focuses on the
histopathology and molecular pathology of colorectal carcinoma and its precursor lesions, with an emphasis
on their clinical relevance.
death in the United States. Pathologic examination of biopsy, polypectomy and resection specimens
is crucial to appropriate patient managemnt, prognosis assessment and family counseling. Molecular testing
plays an increasingly important role in the era of personalized medicine. This review article focuses on the
histopathology and molecular pathology of colorectal carcinoma and its precursor lesions, with an emphasis
on their clinical relevance.